![崔東紅[上海交通大學醫學院博士研究生導師]](/img/d/f1e/nBnauM3X4gzM1kDM5ITOyUTN1UTM1QDN5MjM5ADMwAjMwUzLykzLxAzLt92YucmbvRWdo5Cd0FmLwE2LvoDc0RHa.jpg "崔東紅[上海交通大學醫學院博士研究生導師]")
人物經歷
2005年畢業於復旦大學精神病學與精神衛生專業，獲得復旦大學優秀博士畢業生，同年作為人才引進至上海市精神衛生中心工作。2007.10 -2009.12，在美國耶魯大學醫學院精神衛生系做博士後研究。回國後獲2010年上海市浦江人才，2012年入選上海市公共衛生優先學科帶頭人培養計畫。 2018年度上海市“三八”紅旗手。
研究方向
精神疾病發病的分子機制；抗精神病藥物誘導的代謝障礙機制；精神疾病動物模型構建；利用精神疾病樣本庫篩選精神疾病生物標記物；雙相障礙的語音信號；冥想調節機體內環境的腦-體機制。
研究成果
自1999年以來，主要從事精神分裂症和雙相障礙的臨床基礎研究，主要是病因機制及生物標記物研究，在我國最早“套用基因表達譜晶片尋找精神分裂症相關基因”並獲得2004年“烏魯木齊市科技進步一等獎”（排名第一），“2004年度《中華精神科雜誌》優秀論文一等獎”。2005年“上海市高校科技發明創造獎”（排名第一）。之後，先後主持過精神分裂症相關的四個國家自然科學基金面上項目（基金號30670755，81171266，81271481，81671336）多項省部級重點項目，作為項目負責人主持一項科技部重點研發精準醫學項目（2017YFC0909200），作為骨幹參與過兩項科技部重大項目。還主持過兩項雙相障礙相關項目（YG2012ZD04，GWDTR201230）以及在國際上首次發表了AF1q、TXNIP、APC、ASAH1等精神分裂症新易感基因，以及NGFB是雙相障礙與物質依賴共享基因，還發現抗精神病藥物治療精神分裂症發生代謝障礙的風險預警因子及在中樞和外周的作用機制。在JCI、Molecular Psychiatry、Psychoneuroendocrinology等發表論文70餘篇，申請專利4項、編寫專著4部。
學術兼職
中國神經科學會精神病學基礎與臨床分會常委兼秘書長、上海市遺傳學會理事、中國生物醫學工程組織樣本庫分會委員、上海市健康科技協會基因健康專業委員會常委、上海市重性精神病重點實驗室專家委員會專家、國家重點研發項目精準醫學項目負責人、上海市醫學會整合醫學分會委員。
代表論文
1 、Cui D#*, Peng Y,Xu Y, Qi D, Bucala R.Macrophage migrationinhibitory factor mediates metabolic dysfunction induced by atypicalantipsychotic therapy.JClin Invest.2018 Nov1;128(11):4997-5007.(SCI) IF=13.251
2 、ShengJL,Yuan TF,Cui DH*. Theeffects of Mindfulness Meditation on hallucination and delusion in severeschizophrenia patients with more than 20 years‘ medical history. CNS NeurosciTher. 2018 Sep 28. (SCI) IF=3.495
3 、LinY, Peng Y, Zhou R,Cui D*.SerumIL-1ra, a novel biomarker predicting olanzapine-induced hypercholesterolemiaand hyperleptinemia in schizophrenia.ProgNeuropsychopharmacol Biol Psychiatry.2018 Jun 8;84(Pt A):71-78. (SCI) IF=4.185
4 、ZhangJ, Pan Z, Gui C,Cui D*.Analysis on speech signal features ofmanic patients.J Psychiatr Res.2018 Mar;98:59-63. (SCI) IF=4
5 、XueT, Li H, Wang MT,Cui DH*.Mindfulnessmeditation improves metabolic profiles in healthy and depressive participants.CNSNeurosci Ther. 2018 Jun;24(6):572-574. (SCI) IF=3.495
6 、ZhuC, Xu J, Chen J,Cui D*.Lossof Microglia and Impaired Brain-Neurotrophic Factor Signaling Pathway in aComorbid Model of Chronic Pain and Depression.Front Psychiatry.2018 Oct 4;9:442. (SCI) IF=2.857
7 、JZhang ,Z Pan ,Cui D*. Analysis onspeech signal features of manic patients. J PSYCHIATR RES .2018Mar;98:59-63. (SCI) IF=4.183
8 、SuY, Ding W,Cui D*.TheInteraction of TXNIP and AFq1 Genes Increases the Susceptibility ofSchizophrenia. Mol Neurobiol. 2017 Aug;54(6):4806-4812 (SCI) IF=6.19
9 、Li Z, Wang Z,Cui D*.ReducedENA78 levels as novel biomarker for major depressive disorder and venlafaxineefficiency: Result from a prospective longitudinal study. PSYCHONEUROENDOCRINO.Psychoneuroendocrinology.2017 Jul;81:113-121. (SCI) IF=4.788
10 、JuP,Cui D*. The involvement ofN-methyl-d-aspartate receptor (NMDAR) subunit NR1 in the pathophysiology ofschizophrenia. Acta Biochim Biophys Sin (Shanghai). 2016Mar;48(3):209-19.
11 、PengY, Xu Y,Cui D*. Wnt SignalingPathway in Schizophrenia. CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS.2014;13(5):755-764.
12 、DiXu, Jing Zhang,Donghong Cui*, JieZhu, Acoustic Analysis and Identification of Manic Psychosis Patients,Intelligent Signal Processing Conference 2013,2 - 3 December 2013, London, UK
13 、LinZ, Su Y, Zhang C, Xing M, Ding W, Liao L, Guan Y, Li Z,Cui D*. The interaction of BDNF and NTRK2 gene increases thesusceptibility of paranoid schizophrenia. PLoS One. 2013 Sep 17;8(9):e74264.
14 、LiZ, Qi D, Chen J, Zhang C, Yi Z, Yuan C, Wang Z, Hong W, Yu S,Cui D*, Fang Y. Venlafaxine inhibitsthe upregulation of plasma tumor necrosis factor-alpha (TNF-α) in the Chinesepatients with major depressive disorder: a prospective longitudinal study.Psychoneuroendocrinology. 2013 Jan;38(1):107-14.
15 、WangX,Cui D*, Wang Z, Fan Q, Xu H, QiuJ, Chen J, Zhang H, Jiang K, Xiao Z. Cross-sectional comparison of the clinicalcharacteristics of adults with early-onset and late-onset obsessive compulsivedisorder. J Affect Disord. 2012 Feb;136(3):498-504.
16 、ZhangH, Li D, Su Y, Jiang S, Xu Y, Jiang K,CuiD*. Identification of the N-acylsphingosine amidohydrolase 1 gene (ASAH1)for susceptibility to schizophrenia in a Han Chinese population. World J BiolPsychiatry. 2012 Feb;13(2):106-13.
17 、Cui D#and Jiang K, Research in China on themolecular genetics of schizophrenia, Shanghai Archives of Psychiatry, 2012 (4):187-199.
18 、YuJ, Qi D, Xing M, Li R, Jiang K, Peng Y,CuiD*. MK-801 induces schizophrenic behaviors through downregulating Wntsignaling pathways in male mice. Brain Res. 2011 Apr 18;1385:281-92.
19 、Cui D#, Zhang H, Yang BZ, Listman JB, Li D, PriceLH, Carpenter LL, Tyrka AR, Anton RF, Kranzler HR, Gelernter J. Variation inNGFB is associated with primary affective disorders in women. Am J Med Genet BNeuropsychiatr Genet. 2011 Jun;156B(4):401-12.
20 、Cui DH#, Jiang KD, Jiang SD, Xu YF, Yao H. The tumorsuppressor adenomatous polyposis coli gene is associated with susceptibility toschizophrenia. Mol Psychiatry. 2005 Jul;10(7):669-77.
